General Clinical Chemistry Analyzers and Accessories
Abcam LGK974, 1MG
MW 396.4 Da, Purity >=98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 7-Cl-O-Nec1, metabolically stable RIP1 inhibitor, 5MG
MW 277.7 Da, Purity >98%. Necrostatin-1 (ab141053) analog with superior selectivity and metabolic stability in blocking RIP1. No off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1. Higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC₅₀ = 210 nM vs. EC₅₀ = 490 nM).
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Cefpodoxime
Chemical. CAS 80210-62-4. Formula C15H17N5O6S2. MW 427.46. Synthetic. Cefpodoxime is a metabolite of cefpodoxime proxetil, an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria MIC90 ranges from 0.015-8 µg/ml. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls.
Abcam HDM-201 (Siremadlin), 5MG
MW 555.4 Da, Purity >=98%. Potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam TW-37, 100MG
MW 573.7 Da, Purity >98%. Small-molecule inhibitor of BCL-2 (Ki = 0.29 μM). Inhibits multiple BCL-2 family members including BCL-XL (Ki = 1.11 μM) and MCL-1 (Ki= 0.26 μM). Binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2. Significant anti-proliferative and pro-apoptotic activity in lymphoma cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AZ-20, 25MG
MW 412.5 Da. Potent and selective ATR kinase inhibitor (IC₅₀ = 5 nM in vitro; IC₅₀ = 50 nM in carcinoma cell lines). Selective versus mTOR (8-fold). Displayed selectivity versus a panel of 442 kinases.Inhibits LoVo colorectal adenocarcinoma tumor cell growth.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ryuvidine, 25MG
MW 284.3 Da, Purity >98%. Inhibits (IC₅₀ = 500 nM) KMT5A / SETD8 / Pr-SET7 and suppresses H4JK20 monomethylation in vitro. Weakly active against Cdk4 (IC₅₀ = 6 μM). Induces S-phase accumulation in HEK-293 cells. Cytotoxic towards a number of human cancer cell lines. May induce the DNA damage response.
The product is subject to the following: Abcam Restricted Use Statement
Abcam IO x 2, HIF-1alpha prolyl hydro x ylase-2 (PHD2) inhibitor, 5MG
MW 352.3 Da, Purity >98%. Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor (IC₅₀ = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.
The product is subject to the following: Abcam Restricted Use Statement
YMC America, Inc Tri BioC18Acc 300A 3um 5x.5mm
YMC-Triart phases are based on organic/inorganic hybrid particles that combine the high mechanical stability and efficiency of a silica-based packing material with the robust chemical stability of a polymer-based packing material This versatile resin is produced using tightly controlled particle formation technology adapted from micro-reactor technology The resulting uniform particle and pore size distributions as well as the smooth surface greatly contribute to excellent peak shape and separation reproducibility In addition YMC-Triart materials are highly resilient and robust when used at extreme pH elevated temperature and high pressure
YMC America, Inc Tri BioC18 300A 5um 10x30mm
YMC-Triart phases are based on organic/inorganic hybrid particles that combine the high mechanical stability and efficiency of a silica-based packing material with the robust chemical stability of a polymer-based packing material This versatile resin is produced using tightly controlled particle formation technology adapted from micro-reactor technology The resulting uniform particle and pore size distributions as well as the smooth surface greatly contribute to excellent peak shape and separation reproducibility In addition YMC-Triart materials are highly resilient and robust when used at extreme pH elevated temperature and high pressure
YMC America, Inc TriBioC18Acc 300A 1.9um 5x.5mm
YMC-Triart phases are based on organic/inorganic hybrid particles that combine the high mechanical stability and efficiency of a silica-based packing material with the robust chemical stability of a polymer-based packing material This versatile resin is produced using tightly controlled particle formation technology adapted from micro-reactor technology The resulting uniform particle and pore size distributions as well as the smooth surface greatly contribute to excellent peak shape and separation reproducibility In addition YMC-Triart materials are highly resilient and robust when used at extreme pH elevated temperature and high pressure
YMC America, Inc Tri BioC18 300A 5um 10x2.1mm
YMC-Triart phases are based on organic/inorganic hybrid particles that combine the high mechanical stability and efficiency of a silica-based packing material with the robust chemical stability of a polymer-based packing material This versatile resin is produced using tightly controlled particle formation technology adapted from micro-reactor technology The resulting uniform particle and pore size distributions as well as the smooth surface greatly contribute to excellent peak shape and separation reproducibility In addition YMC-Triart materials are highly resilient and robust when used at extreme pH elevated temperature and high pressure